CD276 Monoclonal Antibody - BT-MCA4390

CD276 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4390-50, BT-MCA4390-100

Citations, Manuals and MSDS Available upon request.

Background: Costimulatory B7 molecules (e.g., B7-1, or CD80; MIM 112203) signal through CD28 (MIM 186760) family molecules such as CD28, CTLA4 (MIM 123890), and ICOS (MIM 604558). May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

Research Areas: Immunology

Target Protein: CD276

Applications: IHC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 6A1

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: CD276

Immunogen: Purified recombinant fragment of human CD276 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 57kDa

UniProt Accession: Q5ZPR3

Synonyms: B7H3, B7-H3, 4Ig-B7-H3, CD276

GeneID: 80381

Research Use Only