CD319 Monoclonal Antibody - BT-MCA4826

CD319 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4826-50, BT-MCA4826-100

Citations, Manuals and MSDS Available upon request.

Background: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).

Research Areas: Others

Target Protein: CD319

Applications: WB, IHC, FCM

Clonality: Monoclonal

Clone ID: 7A8D5

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: CD319

Immunogen: Purified recombinant fragment of human CD319 (AA: extra(23-226)) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 37.4kda

UniProt Accession: Q9NQ25

Synonyms: 19A, CS1, SLAMF7, CRACC

GeneID: 57823

Research Use Only