CD33 Monoclonal Antibody - BT-MCA4839

CD33 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4839-50, BT-MCA4839-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene belongs to putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro) and CD33 plays potential key roles in the pathogenesis of Alzheimer's disease (AD)

Research Areas: Immunology

Target Protein: CD33

Applications: IHC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 2C6B7

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: CD33

Immunogen: Purified recombinant fragment of human CD33 (AA: 15-237) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 39.8kDa

UniProt Accession: P20138

Synonyms: p67, SIGLEC3, SIGLEC-3

GeneID: 945

Research Use Only