Product Description

CD35 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66112-50, MB66112-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Complement receptor type 1`(CR1, CD35) is a type I transmembrane glycoprotein that is expressed on the surface of B cells, neutrophils, monocytes and renal podocytes. As a component of the host innate immune system, CR1/CD35 expressed on neutrophils and monocytes binds to ligands coated with the complement opsonins, C3b and C4b, which facilitates phagocytosis and production of proinflammatory cytokines. CR1/CD35 also participates in negative regμlation of the complement cascade through its ability to promote dissociation of C3 and C5 convertases and by serving as one of mμltiple cofactors for Factor-I-mediated cleavage and inactivation of C3b and C4b.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: IHC

Alternate Names: C3BR, Complement receptor type 1, C3b/C4b receptor, CD35

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within human CD35. The exact sequence is proprietary.

Dilution: IHC (1/100 - 1/300)

Purification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Recognizes endogenous levels of CD35 protein.

Molecular Weight: ~ 223kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P17927

Product: Mouse IgG1. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.

Research Use Only