CD40 Monoclonal Antibody - BT-MCA2010

CD40 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2010-50, BT-MCA2010-100

Citations, Manuals and MSDS Available upon request.

Background: This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]

Research Areas: Immunology

Target Protein: CD40

Applications: WB, IHC, FCM

Clonality: Monoclonal

Clone ID: 4E4C6

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: CD40

Immunogen: Purified recombinant fragment of human CD40 (AA: extra(21-193)) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 30.6kDa

UniProt Accession: P25942

Synonyms: p50, Bp50, CDW40, TNFRSF5

GeneID: 958

Research Use Only