CD42B Monoclonal Antibody - BT-MCA4380

CD42B Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4380-50, BT-MCA4380-100

Citations, Manuals and MSDS Available upon request.

Background: Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy.

Research Areas: Others

Target Protein: CD42B

Applications: WB, IHC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 6H6H10

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: CD42B

Immunogen: Purified recombinant fragment of human CD42B (AA: extra 17-183) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 71.5kDa

UniProt Accession: P07359

Synonyms: GP1BA, BSS, GP1B, VWDP, GPIbA, BDPLT1, BDPLT3, DBPLT3, GPIbalpha, CD42b-alpha

GeneID: 2811

Research Use Only