CD45 Monoclonal Antibody - BT-MCA3642

CD45 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3642-50, BT-MCA3642-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

Research Areas: Others

Target Protein: CD45

Applications: IHC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 1B9B10

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: CD45

Immunogen: Purified recombinant fragment of human CD45 (AA: extra 431-577) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 147.3kDa

UniProt Accession: P08575

Synonyms: PTPRC, LCA, LY5, B220, L-CA, T200, CD45R, GP180

GeneID: 5788

Research Use Only