CD46 Monoclonal Antibody - BT-MCA3419

CD46 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3419-50, BT-MCA3419-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

Research Areas: Immunology

Target Protein: CD46

Applications: WB, ICC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 5A8C11

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: CD46

Immunogen: Purified recombinant fragment of human CD46 (AA: extra 35-179) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 43.7kDa

UniProt Accession: P15529

Synonyms: MCP, TLX, AHUS2, MIC10, TRA2.10

GeneID: 4179

Research Use Only