Product Description

CD61 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66504-50, MB66504-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Integrins are heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival . The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities . Integrins not only transmit signals to cells in response to the extracellμlar environment (outside-in signaling), but also sense intracellμlar cues to alter their interaction with the extracellμlar environment (inside-out signaling) . αIIβ3 and αVβ3 are the two β3 containing integrins which are prominently expressed in hematopoietic cells and angiogenic endothelial cells and perform adhesive functions in hemostasis, wound healing and angiogenesis. Tyr773 and Tyr785 (usually referred to as Tyr747 and Tyr759 based on the chicken sequence) are phosphorylated upon ligand binding . Phosphorylation of these tyrosine residues is required for certain ligand-induced signaling . Thr779 (corresponding to Thr753 of the chicken sequence) of integrin β3 in the platelet specific αIIβ3 is phosphorylated by PKD and/or Akt, which may modμlate integrin association with other signaling molecμles.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: GP3A, Integrin beta-3, Platelet membrane glycoprotein IIIa, GPIIIa, CD61

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Purified recombinant human Integrin beta 3(N-terminus) protein fragments expressed in E.coli.

Dilution: WB (1/500 - 1/1000)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of CD61 protein.

Molecular Weight: ~ 100 kDa

Pathway: Regμlation of Actin Dynamics, MAPK Erk in Growth and Differentiation Pathway, PI3K AKT signaling

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P05106

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Research Use Only