Product Description

CD79a Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66155-50, MB66155-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Antigen receptors found on the surface of B cells contain a heterodimeric signaling component composed of CD79A and CD79B, also known as Ig α and Ig β, respectively . Presence of this receptor complex is essential for B cell development and function. Together these two proteins and the associated B cell receptor (BCR) initiate intracellμlar signaling following antigen binding . An immunoreceptor tyrosine-based activation motif (ITAM) found in the CD79A intracellμlar region appears to be important for its function . Antigen binding precedes formation of the CD79A and CD79B heterodimer and subsequent activation of receptor associated kinases . Research has shown that CD79A is a marker for B-lineage lymphoblastic leukemia . Additionally, investigators have found that mutations in the CD79A (MB1) gene are associated with abnormally low levels of functional B cell receptors in some cases of chronic B cell lymphocytic leukemia .

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: IHC

Alternate Names: IGA, MB1, B-cell antigen receptor complex-associated protein alpha chain, Ig-alpha, MB-1 membrane glycoprotein, Membrane-bound immunoglobμlin-associated protein, Surface IgM-associated protein, CD79a

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within human CD79a. The exact sequence is proprietary.

Dilution: IHC (1/100 - 1/300)

Purification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Recognizes endogenous levels of CD79a protein.

Molecular Weight: ~ 25 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P11912

Product: Mouse IgG2b. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.

Research Use Only