Product Description

CD85f Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4195-50, ES4195-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Alternate Names: LILRA5, ILT11, LILRB7, LIR9, Leukocyte immunoglobulin-like receptor subfamily A member 5, CD85 antigen-like family member F, Immunoglobulin-like transcript 11, ILT-11, Leukocyte immunoglobulin-like receptor 9, LIR-9, CD85f

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human LILRA5. AA range:141-190

Isotype: IgG

Target: CD85f

Specificity: CD85f Polyclonal Antibody detects endogenous levels of CD85f protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed mostly in tissues of the hematopoietic system, including bone marrow, spleen, lymph node and peripheral leukocytes, Among leukocytes, monocytes and neutrophils express the highest level, Expressed in CD14+ monocytes, but not in T-cells, B-cells or natural killer (NK) cells (at protein level),

Observed Band (KD): 33kD

Fields: Osteoclast differentiation, B cell receptor signaling pathway

Function: Function: May plays a role in triggering innate immune responses. Seems not play a role for any class I MHC antigens recognition
Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
Tissue Specificity: Expressed mostly in tissues of the hematopoitic system, including bone marrow, spleen, lymph node and peripheral leukocytes. Among leukocytes, monocytes and neutrophils express the highest level. Expressed in CD14+ monocytes, but not in T-cells, B-cells or natural killer (NK) cells (at protein level)

Subcellular Location: Cell membrane, Single-pass type I membrane protein, [Isoform 3]: Secreted

Storage and Stability: -20°C/1 year

Gene Name: LILRA5

Protein Name: Leukocyte immunoglobulin-like receptor subfamily A member 5

Research Use Only