Product Description

CDA7L Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP14841-20, BT-AP14841-50, BT-AP14841-100

Citations, Manuals and MSDS Available upon request.

Background: Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.,induction:By MYC overexpression in a concentration dependent manner in neuroblastoma cell line.,miscellaneous:Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation.,subcellular location:Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.,subunit:Interacts with MYC and PSIP1.,tissue specificity:Ubiquitous. Overexpressed in medulloblastoma.,

Research Areas: Cancer; Cell biology; Epigenetics and nuclear signaling; Signal transduction

Target Protein: CDCA7L

Applications: WB, ELISA

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Cell division cycle-associated 7-like protein

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q96GN5; Mouse: Q922M5; Rat: Q4G059

Synonyms: Cell division cycle-associated 7-like protein;Protein JPO2;Transcription factor RAM2

GeneID: Human: 55536

Research Use Only