CDC2 Monoclonal Antibody - BT-MCA4124

CDC2 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4124-50, BT-MCA4124-100

Citations, Manuals and MSDS Available upon request.

Background: The cell division control protein cdc2, also known as cyclin-dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S-phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.

Research Areas: Others

Target Protein: CDC2

Applications: WB, IHC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 8C5A6

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: CDC2

Immunogen: Purified recombinant fragment of CDC2 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 34kDa

UniProt Accession: P06493

Synonyms: CDC2, CDC28A, P34CDC2, MGC111195, DKFZp686L20222, CDK1

GeneID: 983

Research Use Only