Product Description

Cdc42EP3 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4516-50, ES4516-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42 function. The encoded protein is involved in actin cytoskeleton re-organization during cell shape changes, including pseudopodia formation. A pseudogene of this gene is found on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: CDC42EP3, BORG2, CEP3, Cdc42 effector protein 3, Binder of Rho GTPases 2, MSE55-related Cdc42-binding protein

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from the N-terminal region of human Cdc42EP3.

Isotype: IgG

Target: Cdc42EP3

Specificity: Cdc42EP3 Polyclonal Antibody detects endogenous levels of Cdc42EP3 protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Highly expressed in the heart and weakly in the brain,

Observed Band (KD): 26kD

Function: Function: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts
Similarity: Belongs to the BORG/CEP family
Similarity: Contains 1 CRIB domain
Subunit: Interacts with RHOQ and CDC42, in a GTP-dependent manner, and with SEPT7
Tissue Specificity: Highly expressed in the heart and weakly in the brain

Subcellular Location: Endomembrane system, Peripheral membrane protein Cytoplasm, cytoskeleton

Storage and Stability: -20°C/1 year

Gene Name: CDC42EP3

Protein Name: Cdc42 effector protein 3

Mouse Gene ID: 260409

Mouse SwissProt Number: Q9CQC5

Research Use Only