CDH1 Monoclonal Antibody - BT-MCA2220

CDH1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2220-50, BT-MCA2220-100

Citations, Manuals and MSDS Available upon request.

Background: E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.

Research Areas: Signal transduction, Cancer, Developmental biology

Target Protein: CDH1

Applications: WB

Reactivity: Human, Mouse, Monkey

Clonality: Monoclonal

Clone ID: 7A2

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: CDH1

Immunogen: Purified recombinant fragment of human CDH1 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 135kDa

UniProt Accession: P12830

Synonyms: UVO, CDHE, ECAD, LCAM, Arc-1, CD324, CDH1

GeneID: 999

Research Use Only