CDH1 Monoclonal Antibody - BT-MCA3115

CDH1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3115-50, BT-MCA3115-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.

Research Areas: Signal transduction, Cancer, Developmental biology

Target Protein: CDH1

Applications: WB, IHC, FCM

Clonality: Monoclonal

Clone ID: 6G2B3

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: CDH1

Immunogen: Purified recombinant fragment of human CDH1 (AA:extra(155-354)) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 97.5kDa

UniProt Accession: P12830

Synonyms: UVO, CDHE, ECAD, LCAM, Arc-1, BCDS1, CD324

GeneID: 999

Research Use Only