CDK4 Monoclonal Antibody - BT-MCA3483

CDK4 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3483-50, BT-MCA3483-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

Research Areas: Cell Biology

Target Protein: CDK4

Applications: WB, IHC, FCM

Clonality: Monoclonal

Clone ID: 4G9F1

Host: Mouse

Isotype: Mouse IgG2a

Full Product Name: CDK4

Immunogen: Purified recombinant fragment of human CDK4 (AA: 77-303) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 33.7kda

UniProt Accession: P11802

Synonyms: CMM3, PSK-J3

GeneID: 1019

Research Use Only