CDK9 Polyclonal Antibody - E-AB-91227

CDK9 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-91227-60, E-AB-91227-120, E-AB-91227-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: CDK9

Target Synonym: CDK9; C-2k; CDC2L4; CTK1; PITALRE; TAK

Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Immunology, Microbiology

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse, Rat

Application: WB

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: P50750

Background: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.

Concentration: 1mg/mL

Immunogen: Recombinant fusion protein of human CDK9

Buffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.

Purification Method: Affinity purification

Dilution: WB 1:1000-1:3000

Calculated MW: 42kDa/53kDa

Observed MW: 40KDa/55KDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only