CDKN1B Monoclonal Antibody - BT-MCA3324

CDKN1B Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3324-50, BT-MCA3324-100

Citations, Manuals and MSDS Available upon request.

Background: p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. Decreased levels of p27Kip1, mainly due to proteosomal degradation, are found in various epithelial tumors originating from lung, breast, colon, ovary, esophagus, thyroid and prostate.Tissue specificity: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.

Research Areas: Cell Biology

Target Protein: CDKN1B

Reactivity: Human

Clonality: Monoclonal

Clone ID: 3D8

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: CDKN1B

Immunogen: Purified recombinant fragment of human CDKN1B expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 22kDa

UniProt Accession: P46527

Synonyms: KIP1, MEN4, CDKN4, MEN1B, P27KIP1, CDKN1B

GeneID: 1027

Research Use Only