CDKN2A Monoclonal Antibody - BT-MCA2185

CDKN2A Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2185-50, BT-MCA2185-100

Citations, Manuals and MSDS Available upon request.

Background: This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

Research Areas: Others

Target Protein: CDKN2A

Applications: WB, IHC, FCM

Clonality: Monoclonal

Clone ID: 5B6A8

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: CDKN2A

Immunogen: Purified recombinant fragment of human CDKN2A (AA: 1-156) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 16.5kDa

UniProt Accession: P42771

Synonyms: ARF, MLM, P14, P16, P19, CMM2, INK4, MTS1, TP16, CDK4I, CDKN2, INK4A, MTS-1, P14ARF, P19ARF, P16INK4, P16INK4A, P16-INK4A

GeneID: 1029

Research Use Only