Product Description

cGAS Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES15063-50, ES15063-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human M21D1 AA range: 35-85

Isotype: IgG

Target: M21D1

Specificity: This antibody detects endogenous levels of M21D1 at Human

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in the monocytic cell line THP1,

Molecular Weight (Da): 57kD

Fields: Cytosolic DNA-sensing pathway, Shigellosis, Human cytomegalovirus infection, Herpes simplex virus 1 infection, Human immunodeficiency virus 1 infection, Coronavirus disease - COVID-19

Subcellular Location: Nucleus Chromosome Cell membrane, Peripheral membrane protein Cytoplasm, cytosol Mainly localizes in the nucleus, and at low level in the cytosol (PubMed:31808743, PubMed:31544964) On chromosomes, enriched on centromeric satellite and LINE DNA repeat elements (PubMed:30811988) Exported from the nucleus to the cytosol in a XPO1/CRM1 via the nuclear export signal in response to DNA stimulation (PubMed:33406424) Outside the nucleus, localizes at the cell membrane as a peripheral membrane protein in resting conditions: association to the cell membrane is mediated via binding to phosphatidylinositol 4, 5-bisphosphate (PtdIns(4, 5)P2) (PubMed:30827685) Localization at the cell membrane is required to limit the recognition of self-DNA (PubMed:30827685) Following detection of double-st

Storage and Stability: -20°C/1 year

Gene Name: MB21D1 cGAS C6orf150

Protein Name: M21D1

Research Use Only