CHD8 Polyclonal Antibody - BT-AP14939

CHD8 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP14939-20, BT-AP14939-50, BT-AP14939-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a DNA helicase that functions as a transcription repressor by remodeling chromatin structure. It binds beta-catenin and negatively regulates Wnt signaling pathway, which plays a pivotal role in vertebrate early development and morphogenesis. Mice lacking this gene exhibit early embryonic death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research Areas: Epigenetics and nuclear signaling

Target Protein: CHD8

Applications: IHC-p, IF

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Chromodomain-helicase-DNA-binding protein 8

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q9HCK8; Mouse: Q09XV5; Rat: Q9JIX5

Synonyms: Chromodomain-helicase-DNA-binding protein 8;CHD-8;EC 3.6.4.12;ATP-dependent helicase CHD8;Helicase with SNF2 domain 1

GeneID: Human: 57680

Research Use Only