CHK2 Monoclonal Antibody - BT-MCA3966

CHK2 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3966-50, BT-MCA3966-100

Citations, Manuals and MSDS Available upon request.

Background: CHK2: CHK2 checkpoint homolog (S. pombe). In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Three transcript variants encoding different isoforms have been found for this gene.

Research Areas: Others

Target Protein: CHK2

Applications: WB, IHC, ICC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 1C12B8

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: CHK2

Immunogen: Purified recombinant fragment of human CHK2 (aa481-531) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 61kDa

UniProt Accession: O96017

Synonyms: CDS1, LFS2, CHEK2

GeneID: 11200

Research Use Only