Product Description

ChoKB (E324) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS2377-50, BS2377-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9Y259

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC

All Applications: IHC: 1:50~1:200

Background: The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. Choline kinase, the initial enzyme in the sequence, plays a role in cell growth proliferation. A related protein, ChoKB (also, known as choline kinase beta), is a 395 amino acid enzyme that catalyzes the phosphorylation of choline by ATP in the presence of magnesium, thereby yielding phosphocholine and ADP. Like all choline kinases, ChoKB possesses ethanoalamine kinase activity and catalyzes the phosphorylation of ethanolamine. The gene encoding ChoKB is located less than 1 kb upstream of the CPT1B gene, suggesting that the ChoKB gene may regulate transcription CPT1B. In mice, mutations and/or deletions in the gene encoding ChoKB are the cause of hindlimb muscular dystrophy and neonatal bone deformity.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of ChoKB (E324) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.

Bioworld Molecular Weight: ~ 45 kDa

Specificity: ChoKB (E324) polyclonal antibody detects endogenous levels of ChoKB protein.

Alternative Name: Choline/ethanolamine kinase; Choline kinase beta; Short name=CK; CKB; Choline kinase-like protein; Ethanolamine kinase; Short name=EK; Ethanolamine kinase beta; EKB; choline/ethanolamine kinase beta; CKEKB; CHKB; CHETK; CHKL

Immunogen: Synthetic peptide, corresponding to amino acids 300-342 of Human ChoKB.

Conjugate: Unconjugated

Modification: Unmodified