Product Description

CHSTE Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES9495-50, ES9495-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the HNK-1 family of sulfotransferases. The encoded protein transfers sulfate to the C-4 hydroxyl of N-acetylgalactosamine residues in dermatan sulfate. Mutations in this gene have been associated with adducted thumb-clubfoot syndrome.[provided by RefSeq, Mar 2010],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: IgG

Target: CHSTE

Specificity: CHSTE Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Widely expressed, Expressed at high level in pituitary gland, placenta, uterus and thyroid,

Observed Band (KD): 41kD

Fields: Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate

Function: Function: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA
Similarity: Belongs to the sulfotransferase 2 family
Tissue Specificity: Widely expressed. Expressed at high level in pituitary gland, placenta, uterus and thyroid

Subcellular Location: Golgi apparatus membrane, Single-pass type II membrane protein

Storage and Stability: -20°C/1 year

Gene Name: CHST14 D4ST1 UNQ1925/PRO4400

Protein Name: Carbohydrate sulfotransferase 14 (EC 2.8.2.35) (Dermatan 4-sulfotransferase 1) (D4ST-1) (hD4ST1)

Mouse SwissProt Number: Q80V53

Research Use Only