CK17 Monoclonal Antibody - BT-MCA3106

CK17 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3106-50, BT-MCA3106-100

Citations, Manuals and MSDS Available upon request.

Background: CK17, also known as KRT17, it is the type I intermediate filament chain keratin 17. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.

Research Areas: Others

Target Protein: CK17

Applications: WB, IHC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 3B12

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: CK17

Immunogen: Purified recombinant fragment of CK17 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 49kDa

UniProt Accession: Q04695

Synonyms: PC, K17, PC2, PCHC1, KRT17

GeneID: 3872

Research Use Only