Product Description

Cleaved-Caspase 6 p18 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BZ16406-50, BZ16406-100

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: P55212

Host: Rabbit

Reactivity: Human, Rat

Applications: WB, IHC-P, ELISA

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100 ELISA: 1/10000

Background: Caspase-6 (Mch2) is one of the major executioner caspases functioning in cellular apoptotic processes. Upon apoptotic stimulation, initiator caspases such as caspase-9 are cleaved and activated. The activated upstream caspases further process downstream executioner caspases, such as caspase-3 and caspase-6, by cleaving them into large and small subunits, thereby initiating a caspase cascade leading to apoptosis. One of the major targets for caspase-6 is the membrane associated protein lamin A.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 33 kDa; Observed MW: 20,35 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Cleaved-Caspase 6 p18 in various lysates using Cleaved-Caspase 6 p18 antibody., Western blot analysis of Cleaved-Caspase 6 p18 in 293 lysates using Cleaved-Caspase6 p18 antibody., Immunohistochemistry analysis of paraffin-embedded Human lung carcinoma tissue using Caspase 6 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. Sample with blocking peptide on the right., Western blot analysis of Cleaved-Caspase 6 p18 in 293 lysates treated with Etoposide using Cleaved-Caspase 6 p18 antibody. The Lane on the right is blocked with the synthesized peptide.

Alternative Name: CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2

Immunogen: The antiserum was produced against synthesized peptide derived from human Caspase 6. AA range:130-179

Conjugate: Unconjugated

Modification: Cleaved