Product Description

Cleaved-MMP-23 (Y79) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES1047-50, ES1047-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the more telomeric copy of the duplicated region. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: MMP23A, MMP21, MMP23B, MMP21, MMP22, Matrix metalloproteinase-23, MMP-23, Femalysin, MIFR-1, Matrix metalloproteinase-21, MMP-21, Matrix metalloproteinase-22, MMP-22

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human MMP23. AA range:60-109

Isotype: IgG

Target: MMP-23

Specificity: Cleaved-MMP-23 (Y79) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-23 protein resulting from cleavage adjacent to Y79.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Predominantly expressed in ovary, testis and prostate,

Observed Band (KD): 36kD

Function: Cofactor: Binds 1 zinc ion per subunit
Enzyme Regulation: Inhibited by TIMP2
Function: Protease
PTM: N-glycosylated
PTM: Proteolytic cleavage might yield an active form
Similarity: Belongs to the peptidase M10A family
Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
Subcellular Location: A secreted form produced by proteolytic cleavage seems also to exist
Tissue Specificity: Predominantly expressed in ovary, testis and prostate

Subcellular Location: Endoplasmic reticulum membrane, Single-pass type II membrane protein Membrane, Single-pass type II membrane protein A secreted form produced by proteolytic cleavage may also exist

Storage and Stability: -20°C/1 year

Gene Name: MMP23A

Protein Name: Matrix metalloproteinase-23

Mouse Gene ID: 26561

Mouse SwissProt Number: O88676

Rat Gene ID: 94339

Rat SwissProt Number: O88272

Research Use Only