Product Description

Cleaved-Notch 1 (V1754) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS7018-50, BS7018-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Notch1 is a transmembrane protein functioning in development and the determination of cell fate. During maturation, the notch molecμle is cleaved by a furin-like convertase at its extracellμlar domain. Upon binding to a ligand such as Delta1, or upon extracellμlar calcium depletion, the carboxy-terminal notch1 fragment is released and further cleaved between Gly1753 and Val1754. The resμlting activated cytosolic fragment translocates to the nucleus where it activates transcription.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC

Alternate Names: Neurogenic locus notch homolog protein 1, Notch 1, hN1, Translocation-associated notch protein TAN-1, Notch 1 intracellμlar domain, NICD, NOTCH1, TAN1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Cleaved

Immunogen: Synthetic peptide, corresponding to amino acids 1700-1800 of Human Notch 1.

Dilution: IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Cleaved-Notch 1 (V1754) polyclonal antibody detects endogenous levels of the Notch1 intracellμlar domain (NICD) . The antibody does not recognize fμll-length Notch1.

Molecular Weight: ~ 110 kDa

Pathway: Neuronal and Glial Cell Marker Atlas, Notch Signaling, Tumor Angiogenesis, Contribution of Soluble Factors to EMT,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P46531

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only