Product Description

Cleaved-Notch 2 (A1734) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS7043-50, BS7043-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regμlating cell fate decisions. To date, four Notch homologs have been identified in mammals and have been designated Notch 1, Notch 2, Notch 3 and Notch 4. The Notch genes are expressed in a variety of tissues in both the embryonic and adμlt organism, suggesting that the genes are involved in mμltiple signaling pathways. The Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged, Jagged2 and Delta. Jagged can activate Notch and prevent myoblast differentiation by inhibiting the expression of muscle regμlatory and structural genes. Jagged2 is thought to be involved in the development of various tissues whose development is dependent upon epithelial-mesenchymal interactions.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Neurogenic locus notch homolog protein 2, Notch 2, hN2, Notch 2 extracellμlar truncation, Notch 2 intracellμlar domain, NOTCH2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Cleaved

Immunogen: Synthetic peptide, corresponding to amino acids 1734-1800 of Human Notch 2.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Cleaved-Notch 2 (A1734) polyclonal antibody detects endogenous levels of Notch 2 protein intracellμlar domain.

Molecular Weight: ~110 kDa

Pathway: Notch Signaling, Contribution of Soluble Factors to EMT,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q04721

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only