Product Description

Cleaved-Plasminogen HC A short form (V98) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES1073-50, ES1073-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: PLG, Plasminogen

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human PLMN. AA range:79-128

Isotype: IgG

Target: Plasminogen HC A

Specificity: Cleaved-Plasminogen HC A short form (V98) Polyclonal Antibody detects endogenous levels of fragment of activated Plasminogen HC A short form protein resulting from cleavage adjacent to V98.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Present in plasma and many other extracellular fluids, It is synthesized in the liver,

Observed Band (KD): 54kD

Fields: Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Staphylococcus aureus infection, Influenza A

Function: Catalytic Activity: Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products
Disease: Defects in PLG are a cause of thrombophilia [MIM: 188050], a form of recurrent thrombosis
Disease: Defects in PLG may be associated with ligneous conjunctivitis [MIM: 217090]. Ligneous conjunctivitis is an unusual and rare form of chronic conjunctivitis, characterized by chronic tearing and redness of the conjunctivae. Initially, pseudomembranes form on the palpebral surfaces which then progress to thick nodular masses that replace the normal mucosa. Because the pseudomembranes have a woodlike consistency, the disease is termed "ligneous" conjunctivitis. The disease may be associated with pseudomembranous lesions of other mucous membranes in the mouth, nasopharynx, trachea, and female genital tract
Domain: Kringle domains mediate interaction with

Subcellular Location: Secreted Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin Interaction with HRG tethers it to the cell surface

Storage and Stability: -20°C/1 year

Gene Name: PLG

Protein Name: Plasminogen

Mouse Gene ID: 18815

Mouse SwissProt Number: P20918

Rat Gene ID: 85253

Rat SwissProt Number: Q01177

Research Use Only