Product Description

COL11A1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4752-50, ES4752-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: collagen type XI alpha 1 chain(COL11A1) Homo sapiens This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Mutations in this gene are associated with type II Stickler syndrome and with Marshall syndrome. A single-nucleotide polymorphism in this gene is also associated with susceptibility to lumbar disc herniation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: COL11A1, COLL6, Collagen alpha-1(XI) chain

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human Collagen XI alpha1. AA range:581-630

Isotype: IgG

Target: Collagen XI α1

Specificity: COL11A1 Polyclonal Antibody detects endogenous levels of COL11A1 protein.

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. IF 1:100-300 Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Cartilage, placenta and some tumor or virally transformed cell lines, Isoforms using exon IIA or IIB are found in the cartilage while isoforms using only exon IIB are found in the tendon,

Observed Band (KD): 181kD

Fields: Protein digestion and absorption

Function: Alternative Products: Additional isoforms seem to exist. There is alternative usage of exon IIA or exon IIB. Transcripts containing exon IIA or IIB are present in cartilage, but exon IIB is preferentially utilized in transcripts from tendon,Disease: Defects in COL11A1 are the cause of Marshall syndrome [MIM: 154780]. It is an autosomal dominant disorder with ocular, orofacial, auditory and skeletal manifestations. It shares several features with Stickler syndrome, such as midfacial hypoplasia, high myopia, and sensorineural-hearing deficit
Disease: Defects in COL11A1 are the cause of Stickler syndrome type 2 (STL2) [MIM: 604841], also known as Stickler syndrome vitreous type 2. STL2 is an autosomal dominant form of Stickler syndrome, an inherited disorder that associates ocular signs with more or less complete forms of Pierre Robin sequence, bone disorders and sensorineural deafness. Ocular

Subcellular Location: Secreted, extracellular space, extracellular matrix

Storage and Stability: -20°C/1 year

Gene Name: COL11A1

Protein Name: Collagen alpha-1(XI) chain

Mouse Gene ID: 12814

Mouse SwissProt Number: Q61245

Research Use Only