COL1A1 Monoclonal Antibody - BT-MCA3675

COL1A1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3675-50, BT-MCA3675-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]

Research Areas: Signal transduction, Stem cells, Cancer, Tags and, cell markers

Target Protein: COL1A1

Applications: FCM

Clonality: Monoclonal

Clone ID: 4E8G11

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: COL1A1

Immunogen: Purified recombinant fragment of human COL1A1 (AA: 1219-1464) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 139kDa

UniProt Accession: P02452

Synonyms: OI1, OI2, OI3, OI4, EDSC, EDSARTH1

GeneID: 1277

Research Use Only