COL1A2 Monoclonal Antibody - BT-MCA4142

COL1A2 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4142-50, BT-MCA4142-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

Research Areas: Signal Transduction

Target Protein: COL1A2

Applications: ICC, FCM

Clonality: Monoclonal

Clone ID: 4D1A7

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: COL1A2

Immunogen: Purified recombinant fragment of human COL1A2 (AA: 23-79) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 129kDa

UniProt Accession: P08123

Synonyms: OI4, EDSCV, EDSARTH2

GeneID: 1278

Research Use Only