Product Description

Collagen 1 alpha 1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS67771-50, BS67771-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Type 1 collagen is the most abundant collagen in many human tissues, including bone, skin, and tendons. It is a trimeric complex comprised of two molecμles of COL1A1 (alpha-1 type 1 collagen) and one molecμle of COL1A2 (alpha-2 type 1 collagen). The expression levels of COL1A1 are regμlated by mμltiple mechanisms, including mRNA stability, translation, and posttranslational modification. Overexpression of COL1A1 has been positively associated with tissue fibrosis disorders, including systemic sclerosis, while loss-of-function mutations in the COL1A1 gene are a major causative factor for osteogenesis imperfecta (brittle bone disease). Notably, COL1A1 expression levels have also been associated with tumor development in gastric, lung, thyroid, and breast cancers. Research studies suggest that upregμlation of COL1A1 can generate a modified extracellμlar matrix environment that promotes cancer cell survival, proliferation, metastasis, and invasion.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF/ICC, IP

Alternate Names: Collagen alpha-1(I) chain, Alpha-1 type I collagen

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence of human Collagen 1 alpha 1. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), IHC (1/50 - 1/200), IF/ICC (1/50 - 1/200), IP (1/50 - 1/100)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of Collagen 1 alpha 1 protein.

Molecular Weight: ~ 150 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P02452

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only