Cortactin Monoclonal Antibody - BT-MCA0366

Cortactin Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0366-50, BT-MCA0366-100

Citations, Manuals and MSDS Available upon request.

Background: This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.

Research Areas: Signal transduction; Cancer

Target Protein: CTTN

Applications: WB, IHC-p, IF, ELISA

Reactivity: Human,Mouse

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Src substrate cortactin

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q14247; Mouse: Q60598

Synonyms: CTTN; EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1

GeneID: Human: 2017; Mouse: 13043

Research Use Only