Cortactin Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A15054-20, A15054-100
Citations, Manuals and MSDS Available upon request.
Background: This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
Category: Polyclonal Antibodies
Applications: WB, IHC-P, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 62kDa
Observed Molecular Weight: 85kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 2017
SWISS: Q14247
Alternate Names: EMS1; Cortactin
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:2000 IHC-P, 1:50 - 1:100 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Protein phosphorylation, Cancer, Signal Transduction, Cell Biology Developmental Biology, Cell Cycle, Cell Adhesion, Cytoskeleton, Microfilaments, Actins.
NCBI Alias: CTTN
Research Use Only