Cox-11 (F80) Polyclonal Antibody-BS2185

Cox-11 (F80) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS2185-50, BS2185-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9Y6N1

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC

All Applications: IHC: 1:50~1:200

Background: Cytochrome c oxidase (COX) is the terminal enzyme in the electron transfer chain, functioning as a transmembrane proton pump that builds an electrochemical gradient with chemical energy from the reduction of O2. Cytochrome c oxidase assembly protein COX11 is an intracellular mitochondrial membrane protein necessary for the construction of an active COX complex. COX11 contains a single transmembrane helix downstream of the N-terminal, mitochondrial targeting sequence and a C-terminal Cu(I)-binding domain. The assembly of COX requires the delivery of metal cofactors. Along with COX12 and SCO1/2, COX11 acts as a metal ion chaperone necessary for copper insertion into CuA and CuB redox-active copper centers of COX in eukaryotes.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of Cox-11 (F80) pAb in paraffin-embedded human tonsil cancer tissue at 1:50.

Bioworld Molecular Weight: ~ 31 kDa

Specificity: Cox-11 (F80) polyclonal antibody detects endogenous levels of Cox-11 protein.

Alternative Name: Cytochrome c oxidase assembly protein COX11, mitochondrial; COX11

Immunogen: Synthetic peptide, corresponding to amino acids 50-100 of Human Cox-11.

Conjugate: Unconjugated

Modification: Unmodified