CP27B Polyclonal Antibody - BT-AP15083

CP27B Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP15083-20, BT-AP15083-50, BT-AP15083-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.

Research Areas: Metabolism

Target Protein: CYP27B1

Applications: WB, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: O15528; Mouse: O35084; Rat: O35132

Synonyms: 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial;EC 1.14.13.13;25-OHD-1 alpha-hydroxylase;25-hydroxyvitamin D;3 1-alpha-hydroxylase;VD3 1A hydroxylase;Calcidiol 1-monooxygenase;Cytoc

GeneID: Human: 1594

Research Use Only