CRACR2A Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-19269-60, E-AB-19269-120, E-AB-19269-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: CRACR2A
Target Synonym: Calcium release-activated calcium channel regulator 2A; CRAC channel regulator 2A; CRACR2A; EF hand calcium binding domain 4B; EF hand calcium binding domain containing protein 4B; EF-hand calcium-binding domain-containing protein 4B; EFC4B; EFCAB 4B; Efcab4b; FLJ33805; MGC4266
Research Areas: Signal transduction
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human
Application: IHC, ELISA
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: Q9BSW2
Background: Ca2+-binding protein that plays a key role in store-operated Ca2+entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
Concentration: 0.84 mg/mL
Immunogen: Fusion protein of human CRACR2A
Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Purification Method: Antigen affinity purification
Dilution: IHC 1:50-1:200, ELISA 1:5000-1:10000
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only