Crk II Monoclonal Antibody - BT-MCA0387

Crk II Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0387-50, BT-MCA0387-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

Research Areas: Signal transduction; Cancer

Target Protein: CRK

Applications: WB

Reactivity: Human,Mouse,Dog,Rabbit

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Adapter molecule crk

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P46108; Mouse: Q64010; Rat: Q63768

Synonyms: CRK; Adapter molecule crk; Proto-oncogene c-Crk; p38

GeneID: Human: 1398; Mouse: 12928

Research Use Only