CRK Monoclonal Antibody - BT-MCA4528

CRK Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4528-50, BT-MCA4528-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

Research Areas: Signal Transduction

Target Protein: CRK

Applications: IHC, ICC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 3G11C1

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: CRK

Immunogen: Purified recombinant fragment of human CRK expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 42kDa

UniProt Accession: P46108

Synonyms: CRKII

GeneID: 1398

Research Use Only