Crk2 (P215) Polyclonal Antibody-BS1079

Crk2 (P215) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS1079-50, BS1079-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P46108

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC, IF

All Applications: IHC: 1:50~1:200
IF: 1:50~1:200

Background: Crk I and Crk II are encoded by the same gene, which undergoes alternative splicing to yield these two proteins, but differ in their biological activities. Crk II has less transforming activity than Crk I, although both Crk I and Crk II bind to many tyrosine-phosphorylated proteins that bind to GRB2. In addition, Crk II becomes rapidly tyrosine-phosphorylated in response to stimulation with insulin-like growth factor I (IGF-I) and might be involved in the IGF-I receptor signalling pathway.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of Crk2 (P215) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Bioworld Molecular Weight: ~ 42 kDa

Specificity: Crk2 (P215) polyclonal antibody detects endogenous levels of Crk2 protein.

Alternative Name: Adapter molecule crk; Proto-oncogene c-Crk; p38 CRK; CRK; CRKII

Immunogen: Synthetic peptide, corresponding to amino acids 200-250 of Human Crk2.

Conjugate: Unconjugated

Modification: Unmodified