CSK Monoclonal Antibody - BT-MCA4035

CSK Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4035-50, BT-MCA4035-100

Citations, Manuals and MSDS Available upon request.

Background: Carboxy-terminal Src kinase (Csk) is a ubiquitously expressed nonreceptor tyrosine kinase that negatively regulates the Src family kinases (SFK) by phosphorylation of the SFK carboxy-terminal tyrosine. Phosphorylated carboxy-terminal tyrosine binds to the SH2 domain of SFK intramolecularly and leads to folding and inactivation of the SFK . This Csk-catalyzed SFK tyrosine phosphorylation is highly specific and exclusive. The SFK carboxy-terminal tyrosine is the only known physiological substrate of Csk .Tissue specificity: Expressed in lung and macrophages.

Research Areas: Signal Transduction

Target Protein: CSK

Applications: WB, ICC, FCM

Reactivity: Human, Mouse, Monkey, Rat

Clonality: Monoclonal

Clone ID: 5F3

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: CSK

Immunogen: Purified recombinant fragment of human CSK expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 50kDa

UniProt Accession: P41240

Synonyms: MGC117393, CSK

GeneID: 1445

Research Use Only