CSNK2A2 Monoclonal Antibody - BT-MCA3570

CSNK2A2 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3570-50, BT-MCA3570-100

Citations, Manuals and MSDS Available upon request.

Background: Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt.

Research Areas: Signal transduction

Target Protein: CSNK2A2

Applications: WB, FCM

Reactivity: Human, Mouse

Clonality: Monoclonal

Clone ID: 1E1

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: CSNK2A2

Immunogen: Purified recombinant fragment of human CSNK2A2 (AA: 194-350) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 41.2kDa

UniProt Accession: P19784

Synonyms: CK2A2, CSNK2A1, FLJ43934

GeneID: 1459

Research Use Only