Product Description

CtBP1/2 (Phospho Ser158/164) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES20176-50, ES20176-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: cofactor:NAD. Required for efficient interaction with E1A. Cofactor binding induces a conformation change.,function:Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex (By similarity). Co-repressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity.,PTM:ADP-ribosylated, when cells are exposed to brefeldin-A (BFA).,PTM:Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX4.,PTM:The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation.,similarity:Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.,subunit:Interacts with the C-terminus of adenovirus E1A protein, ELK3 and CTIP via their consensus motif P-X-[DNS]-L-[STVA]. Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with FOXP2, HDAC4, HDAC5 and HDAC9. Interacts with GLIS2 but not GLIS1 or GLIS3 (By similarity). Interacts with FOXP1, HIPK2, PNN and NRIP1. Interacts with ZFHX1B and WIZ. Interacts with Epstein-Barr virus EBNA3 and EBNA6.,

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: C-terminal-binding protein 1 (CtBP1, EC 1.1.1.-)

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human CtBP1/2 (Phospho Ser158/164)

Isotype: IgG

Target: CtBP1/2

Specificity: This antibody detects endogenous levels of Human,Mouse,Rat CtBP1/2 (Phospho Ser158/164)

Dilution: WB 1:1000-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in germinal center B-cells,

Observed Band (KD): 48kD

Fields: Wnt signaling pathway, Notch signaling pathway, Pathways in cancer, Chronic myeloid leukemia

Function: negative regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent,regulation of transcription from RNA polymerase II promoter, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, Golgi organization, negative regulation of cell proliferation, negative regulation of biosynthetic process, negative regulation of macromolecule biosynthetic process, negative regulation of macromolecule metabolic process, negative regulation of gene expression, viral reproduction, phosphorylation,negative regulation of transcription, viral infectious cycle, viral genome replication, viral reproductive process, negative regulation of cellular biosynthetic process, regulation of cell proliferation, fat cell differentiation, regulation of transcription, negative regulation of transcription, DNA-dependent, negative regulation

Subcellular Location: Cytoplasm Nucleus

Storage and Stability: -20°C/1 year

Gene Name: CTBP1 CTBP

Protein Name: CtBP1/2 (Phospho Ser158/164)

Mouse Gene ID: 13016

Mouse SwissProt Number: O88712

Rat Gene ID: 29382

Rat SwissProt Number: Q9Z2F5

Research Use Only