Product Description

Ctip2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS90342-50, BS90342-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Bcl-11a (CtIP-1, EVI9, B cell chronic lymphocytic leukemia (CLL)/lymphoma 11A) and Bcl-11b (CtIP-2, RIT1, B cell CLL/lymphoma 11B) genes play crucial roles in lymphopoiesis and influence the progression of hematopoietic malignancies. Disruption of the Bcl-11b locus is linked to T cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice resμlts in T cell lymphoma. Bcl-11 proteins are related C2H2 zinc-finger transcription factors that act as transcriptional repressors. Bcl-11b can interact with the metastasis-associated proteins MTA1 and MTA2 through the amino-terminal region. Bcl-11a is essential for postnatal development and normal lymphopoiesis. The Bcl-11a mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with Bcl-6.

Category: Primary Antibody

Reactivity: Mouse

Host: Rabbit

Applications: WB, IHC, IF, ICC, ELISA

Alternate Names: B cell lymphoma/leukemia 11B, B-cell CLL/Lymphoma 11B, B-cell lymphoma/leukemia 11B, BC11B_HUMAN, BCL-11B, Bcl11B, COUP-TF interacting protein 2, COUP-TF-interacting protein 2, Ctip 2, hRit1, MS1029, Radiation induced tumor suppressor gene 1, Radiation induced tumor suppressor gene 1 protein, Radiation-induced tumor suppressor gene 1 protein, Rit 1, Rit1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human Ctip2 : 331-4630/894

Dilution: WB 1:500 - 1:2000
IHC 1:100 - 1:500
IF 1:100 - 1:500
ICC 1:100 - 1:500
ELISA 1:5000 - 1:10000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Ctip2 polyclonal antibody detects endogenous levels of Ctip2 protein.

Molecular Weight: ~ 95 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9C0K0

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only