Product Description

Cyclin D3 (G277) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1393-50, BS1393-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The inactive ternary complex of cyclin D/CDK4 and p27 Kip1 requires extracellμlar mitogenic stimμli for the release and degradation of p27 concomitant with a rise in cyclin D levels to affect progression through the restriction point and Rb-dependent entry into S-phase. The active complex of cyclin D/CDK4 targets the retinoblastoma protein for phosphorylation, allowing the release of E2F transcription factors that activate G1/S-phase gene expression. Levels of cyclin D protein drop upon withdrawal of growth factors through downregμlation of protein expression and phosphorylation-dependent degradation.Although the D-type cyclins are not fμlly redundant, cyclin D3, like D1, plays a prominent role in differentiation and proliferation, which correlates with higher expression levels of cyclin D3 in various cancers.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC

Alternate Names: CCND 3, CCND3, CyclinD3, Cyclin-D3, D3 type cyclin, G1 S specific cyclin D3, G1/S specific cyclin D3, G1/S-specific cyclin-D3,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 249-299 of Human Cyclin D3.

Dilution: IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Cyclin D3 (G277) polyclonal antibody detects endogenous levels of Cyclin D3 protein.

Molecular Weight: ~ 34 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P30281

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only