Cyclin D3 Monoclonal Antibody - BT-MCA0397

Cyclin D3 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0397-50, BT-MCA0397-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.

Research Areas: Epigenetics and nuclear signaling; Cell biology; Cancer

Target Protein: CCND3

Applications: WB, ELISA

Reactivity: Human,Mouse

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: G1,S-specific cyclin-D3

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P30281; Mouse: P30282

Synonyms: CCND3; G1; S-specific cyclin-D3

GeneID: Human: 896; Mouse: 12445

Research Use Only