Product Description

CYLD Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB67219-50, MB67219-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: CYLD is a cytoplasmic deubiquitinating enzyme encoded by a tumor suppressor gene altered in individuals diagnosed with cylindromatosis, a genetic condition characterized by benign tumors of skin appendages. Functional CYLD deubiquitinase regμlates inflammation and cell proliferation by down regμlating NF-κB signaling through removal of ubiquitin chains from several NF-κB pathway proteins. CYLD is a negative regμlator of proximal events in Wnt/β-catenin signaling and is a critical regμlator of natural killer T cell development. The transcription factor Snail can inhibit CYLD expression, resμlting in melanoma cell proliferation.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB, FC

Alternate Names: CYLD1, KIAA0849, Ubiquitin carboxyl-terminal hydrolase CYLD, Deubiquitinating enzyme CYLD, Ubiquitin thioesterase CYLD, Ubiquitin-specific-processing protease CYLD

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CYLD. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/2000), FC (1/10 - 1/50)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of CYLD protein.

Molecular Weight: ~ 108 kDa

Pathway: Regμlation of Apoptosis, Death Receptor Signaling, Inhibition of Apoptosis, NF-kB Signaling, Wntβ catenin signaling

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9NQC7

Product: Mouse IgG2a kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only